Phosphodiesterase 1 Upregulation in Pulmonary Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.
BACKGROUND Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS We investigated the expression of PDE1 in explanted lungs from idiopathic PAH patients and animal mode...
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ژورنال
عنوان ژورنال: Circulation
سال: 2007
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.106.676809